Cancer-Related Fatigue
Supervised, multimodal exercise is shown to be an
effective intervention against cancer-related fatigue
over and above pharmaceutical treatments.1
Cancer-Related Fatigue (CRF) is a distressing, persistent and subjective sense of physical, emotional and/or cognitive exhaustion related to cancer or cancer treatment that is not proportional to activity engaged in during the day and interferes with everyday functioning.

CRF is one of the most disabling, distressing, unfortunate and common symptoms that individuals with cancer can face … with up to 80 to 90 percent reporting CRF2. And, unfortunately, CRF can persist for years.3 Most consider CRF as a symptom that must be tolerated and more than one-half of individuals will not discuss it with their providers.4 CRF can impact physical health and functioning and may cause a significant financial burden by decreasing the ability to work.2
Treating CRF


For adults with cancer, the evidence for rehabilitation and physical activity to decrease fatigue has grown. Home-based, low-impact exercise or physical activity can lessen fatigue for men with prostate cancer undergoing ADT or radiation, and individuals with lymphoma ovarian or breast cancer.5

A recent systematic review of meta-analyses found an overall significant impact of exercise on CRF in a large majority (76%) of studies.6 In this study, Fuller et al. concluded that although it appears the impact of exercise on fatigue can be less during treatment than after treatment, being more active improves outcomes. However, few individuals actually follow the recommended 150 minutes of exercise per week, which could be due to high levels of fatigue. With community-based rehabilitation, individuals with cancer have the opportunity to work with certified professionals to individualize their physical activity plan for better success.7
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ReVital is a Leader in Cancer Rehabilitation

ReVital’s cancer rehabilitation therapists have been specially trained to prescribe effective treatment plans to help reduce CRF cancer-related fatigue in individuals affected by all cancer types. Our therapists are a valuable part of the cancer care team, and can help to decrease symptom burden and improve quality of life.

1. Mustian KM, Alfano CM, Heckler C, et al. Comparison of pharmaceutical, psychological, and exercise treatments for cancer-related fatigue: a meta-analysis. JAMA oncology. 2017;3(7):961-968.
2. Hofman M, Ryan JL, Figueroa-Moseley CD, Jean-Pierre P, Morrow GR. Cancer-related fatigue: the scale of the problem. The oncologist. 2007;12(Supplement 1):4-10.
3. Bower JE, Ganz PA, Desmond KA, et al. Fatigue in long‐term breast carcinoma survivors: a longitudinal investigation. Cancer. 2006;106(4):751-758.
4. Luthy C, Cedraschi C, Pugliesi A, et al. Patients’ views about causes and preferences for the management of cancer-related fatigue—a case for non-congruence with the physicians? Supportive Care in Cancer. 2011;19(3):363-370.
5. Schmitz KH, Courneya KS, Matthews C, et al. American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Medicine & Science in Sports & Exercise. 2010;42(7):1409-1426.
6. Fuller JT, Hartland MC, Maloney LT, Davison K. Therapeutic effects of aerobic and resistance exercises for cancer survivors: a systematic review of meta-analyses of clinical trials. Br J Sports Med. 2018;52(20):1311-1311.
7. Leach HJ, Covington KR, Pergolotti M, et al. Translating Research to Practice Using a Team-Based Approach to Cancer Rehabilitation: A Physical Therapy and Exercise-Based Cancer Rehabilitation Program Reduces Fatigue and Improves Aerobic Capacity. Rehabilitation Oncology. 2018;36(4):206-213.